Involvement of Aberrant Glycosylation in Thyroid Cancer
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چکیده
منابع مشابه
Involvement of Aberrant Glycosylation in Thyroid Cancer
Glycosylation is one of the most common posttranslational modification reactions and nearly half of all known proteins in eukaryotes are glycosylated. In fact, changes in oligosaccharides structures are associated with many physiological and pathological events, including cell growth, migration and differentiation, and tumor invasion. Therefore, functional glycomics, which is a comprehensive st...
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In this review, the sugar portions of glycoproteins, glycolipids, and glycosaminoglycans constitute the glycome, and the genes involved in their biosynthesis, degradation, transport and recognition are referred to as "glycogenes". The extreme complexity of the glycome requires the regulatory layer to be provided by the epigenetic mechanisms. Almost all types of cancers present glycosylation abe...
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Alternative splicing can alter genome sequence and as a consequence, many genes change to oncogenes. This event can also affect protein function and diversity. The growing number of study elucidate the pathological influence of impaired alternative splicing events on numerous disease including cancer. Here, we would like to highlight the significant role of alternative splicing in cancer biolog...
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Despite increasing detection rates of various forms of extrapulmonary tuberculosis (TB), thyroid involvement with tubercle bacilli is rarely encountered and its imaging features have been reported in less than a handful of cases. Herein, we present the clinical, pathologic and imaging (ultrasound and CT scan) features of TB involvement of the thyroid gland in a 65-year-old woman who presented w...
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Colorectal cancer (CRC) is the fourth leading cause of cancer-related deaths in the world. Drug resistance of tumour cells remains the main challenge toward curative treatments efficiency. Several epidemiologic studies link emergence and recurrence of this cancer to metabolic disorders. Glycosylation that modifies more than 80% of human proteins is one of the most widepread nutrient-sensitive p...
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ژورنال
عنوان ژورنال: Journal of Oncology
سال: 2010
ISSN: 1687-8450,1687-8469
DOI: 10.1155/2010/816595